Protein entrapment in PEGylated lipid nanoparticles
نویسندگان
چکیده
منابع مشابه
Repeated injection of PEGylated solid lipid nanoparticles induces accelerated blood clearance in mice and beagles
Surface modification of nanocarriers with amphiphilic polymer polyethylene glycol (PEG), known as PEGylation, is regarded as a major breakthrough in the application of nanocarriers. However, PEGylated nanocarriers (including liposomes and polymeric nanoparticles) induce what is referred to as the "accelerated blood clearance (ABC) phenomenon" upon repeated injection and consequently they lose t...
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Camptothecin (CPT; (S)-(+)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione) is a highly cytotoxic natural alkaloid that has not yet found use as chemotherapeutic agent due to its poor water-solubility and chemical instability and, as a consequence, no effective administration means have been designed. In this work, camptothecin has been successfully loaded i...
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Objective(s):Despite of wide range applications of polymeric nanoparticles in protein delivery, there are some problems for the field of protein entrapment, initial burst and controlled release profile. Materials and Methods: In this study, we investigated the influence of some changes in PLGA nanoparticles formulation to improve the initial and controlled release profile. Selected parameters ...
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License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be f...
متن کاملProtein corona composition of PEGylated nanoparticles correlates strongly with amino acid composition of protein surface
The affinity of protein surface amino acids for poly(ethylene glycol)(PEG)(reported by the PEG/water ratio in their vicinity) is used to build a quantitative model of protein adsorption on PEGylated nanoparticles.
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2013
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2013.06.006